Assessing Molecular Point-of-Care Testing and Dried Blood Spot for Hepatitis C Virus Screening in People Who Inject Drugs
Background: Injecting drug use is the primary driver of the hepatitis C virus (HCV) is spread throughout the world, and the World Health Organization (WHO) has identified people who inject drugs (PWID) as a key population for targeted for HCV screening and treatment. Point-of-care (POC) tests for hepatitis C and dried blood spot (DBS) samples offer benefits for the management of patients with HCV infection by enhancing HCV testing and linkage to care in different nonclinical settings. The aim of this prospective study was to evaluate the feasibility and acceptance of the use of HCV ribonucleic acid (RNA) and fingerstick DBS POC testing in the centers of socio-medical risk reduction and to describe the treatment cascade among PWID in France.
Methods: Between June 2018 and February 2019, 89 consecutive PWID HCV-seropositive attend two services drug therapy and 1 consumption supervised in Paris were invited to participate in the further evaluation, undergo a review of clinical assessment the liver and blood tests including capillary fingerstick HCV RNA POC whole blood tests and fingerstick DBS sampling.
Results: Of the 89 participants enrolled, HCV RNA was detected in 34 (38.6%) participants. Fingerstick whole blood RNA POC testing and detection of HCV RNA from DBS samples are feasible and acceptable among PWID with no major difference in the detection rate of HCV RNA. Overall, 16 subjects received a pan-genotypic antiviral treatment. The proportion PWID with SVR at 12 weeks was 81.2%, with data for 3 patients were still pending.
Conclusion: One-step screening strategy based on the detection of HCV RNA will engage people in treatment for scale-up of treatment and elimination of HCV. Keywords: HCV RNA screening; dried blood spot; hepatitis C; people who inject drugs; point of care testing.
Assessing Molecular Point-of-Care Testing and Dried Blood Spot for Hepatitis C Virus Screening in People Who Inject Drugs
clinical risk factors and inflammatory biomarkers of acute kidney injury in patients with post-traumatic combat
Background: Post-traumatic acute kidney injury has occurred in every major military conflict since the initial description during World War II. To ensure the proper treatment of victims of war, early detection is critical. This research therefore aims to determine post-traumatic acute injury-related kidney combat-military conflict recently, the former machine learning algorithms to identify clinical variables and biomarkers associated with the development of acute kidney injury post-trauma, and evaluate the effects of post-traumatic kidney injury acute wound healing and nosocomial infections.
Methods: We conducted a retrospective review of clinical cohort of 73 members of the US military service seriously injured were wounded limb-combat related major injury and has amassed characteristics, tested serum and tissue biopsy samples for protein expression and biomarker messenger ribonucleic acid. Bivariate analysis and classification algorithms recursive feature elimination of random forests are used to identify associated characteristics and variables injury biomarker.
Description: CRK, also known as p38, is a protein that in humans is encoded by the CRK gene. This gene is a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. It is mapped to 17p13.3. The protein participates in the Reelin signaling cascade downstream of DAB1. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of Crk functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described.
Description: This recombinant p38 antibody reacts to human p38 MAPK. It may also react to the rat and mouse protein, as predicted by immunogen homology.
Description: P38 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.
Description: P38 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180/Y182
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y323
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IHC-P, IF, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of T180
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat. This p38 antibody is for WB, IF, IHC-P, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from human p38 around the non-phosphorylation site of Y182
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38
Description: A polyclonal antibody for detection of p38 from Human, Mouse, Rat, Chicken. This p38 antibody is for WB, ELISA. It is affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogenand is unconjugated. The antibody is produced in rabbit by using as an immunogen synthesized peptide derived from the C-terminal region of human p38
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is unconjugated.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is unconjugated.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to ATTO 390.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to ATTO 488.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to ATTO 565.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to ATTO 594.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to ATTO 633.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to ATTO 655.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to ATTO 680.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to ATTO 700.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to Alkaline Phosphatase.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to APC .
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to APC/Cy7.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to Biotin.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to Dylight 350.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to Dylight 405.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to Dylight 488.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to Dylight 594.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to Dylight 633.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to FITC.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to HRP.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to PE/ATTO 594.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to PerCP.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to RPE .
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is conjugated to Streptavidin.
Description: A polyclonal antibody for p38 from Human | Mouse | Rat | Bovine | Monkey | rabbit | Pig | Dog | Hamster | Chicken | Sheep | Guinea Pig (Cavia porcellus). The antibody is produced in rabbit after immunization with Human A 20 residue synthetic peptide based on the human p38 with the cysteine residue added and coupled to KLH. The Antibody is tested and validated for WB, IHC, ICC/IF, IP assays with the following recommended dilutions: WB (1:1000), ICC/IF (1:100), IP (1:250). This p38 antibody is unconjugated.
MAPK P38 ELISA Kit| Mouse P38 Mitogen-activated Protein Kinase E
Description: Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK14 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as proinflammatory cytokines or physical stress leading to direct activation of transcription factors. Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each.
Description: MAPK14 is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response.
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Results: The incidence of acute kidney injury posttraumatic is 20.5%. That is, 86% recovery of renal function is basic and only 2 (15%) of acute kidney injury group required renal replacement therapy. Features recursive algorithm can estimate the random forest abolition of post-traumatic acute kidney injury with the area under the curve of 0.93, sensitivity of 0.91 and specificity of 0.91. Acute kidney injury is associated with post-traumatic injury severity scores, epidermal growth factor serum, and tissue activin A receptor type 1, matrix metallopeptidase 10, and X-C motif chemokine ligand 1 expression. Patients with acute post-traumatic injury to the kidneys exhibited poor wound healing and increased incidence of nosocomial infections.
